High estrogen can cause poor skin quality, thickening of fat, low libido, ovarian hyperfunction, extreme fatigue, breast cancer, endometrial cancer, and so on. High ovarian function, hypothalamic and pituitary hyperfunction, non-specific increase in hyperthyroidism and cirrhosis, and increase in sex hormone-binding protein can all cause high estrogen, which is harmful to health. Women with high estrogen tend to have skin allergies and increased pigmentation; their bodies become bloated and will have a lot of fat; their breasts will be of different sizes from left to right and their areolas will be dark; their vaginas will be dry and inelastic, and they will become sexually frigid. High estrogen will promote the growth of uterine fibroids, and adenopituitary tumors and brain tissue hyperplasia are also related to high estrogen. Patients with high estrogen feel excessive fatigue, headaches, joint pain, muscle pain, and in some cases, low fever. Long-term fatigue and unsatisfactory treatment can also cause depression. Most patients with high estrogen are amenorrheic or have scanty menstruation. Due to the abnormal proliferation of the endometrium, it can also cause endometrial cancer to occur. If a woman has the above symptoms, she should go to a regular hospital for a hormone six test, seek medical advice and take appropriate treatment measures.