Pituitary hypertrophy due to pituitary growth hormone adenoma is a common clinical pituitary tumor that affects mostly young and middle-aged people, with no significant difference in the incidence ratio between men and women. Some female patients have early onset, poor disease control and low quality of life. However, for some female patients with well-controlled disease, there are new annoyances. With a high quality of life, it is human nature to have a higher goal. Recently I have had patients ask me if it is possible to get pregnant, then I want to tell them: you can get pregnant, but you also need to meet the following conditions. First, the soil has to be good. What is the soil? That is the uterus. Patients with regular menstrual cycles and no significant decrease in the function of the pituitary sex hormone axis are able to conceive. For some patients with early acromegaly, especially those with early surgery, generally speaking the gonadal axis is normal. Second, the weather conditions have to be good. What are weather conditions? That is the mother must be in good health to ensure the baby can develop smoothly once your baby has settled in your womb. This requires a good assessment of the patient’s mother’s condition prior to pregnancy. Only a sufficiently stable condition, that is, a pregnancy with well-controlled hormone levels, can minimize the risks associated with complications such as gestational hypertension and gestational diabetes. Researchers in France found that patients with well-controlled disease had a normal pregnancy and delivered normal babies. Generally speaking, 2/3 of mothers with large limbs are able to have a successful pregnancy and a healthy birth. Again, attention is important. What to pay attention to? Pay attention to the changes in yourself during pregnancy and be a responsible person for yourself. In general, the hormones of a mother with a large limb increase rapidly during pregnancy, including that pesky growth hormone, which makes it possible for the beauty that has been so easily restored to go downhill again. As the saying goes, there are gains and losses, and this is a reflection of the greatness of motherhood. Therefore, mothers with large limbs should continuously monitor their hormone levels during pregnancy and ignore any normal increase. Relax, think about your lovely baby coming soon and smile about the future. Therefore, when your condition is well controlled, pregnancy is not difficult and you should not be particularly worried about the birth of a baby with defects. Be confident that the confusion caused by your face is only temporary, but a good heart is eternal.