Redness and swelling of the urethral opening may be due to urethritis, glans and other diseases, after a clear diagnosis, you can use medication under the guidance of the doctor. 1. Urethritis: it is usually due to urethral inflammation that irritates the skin of the urethral opening, which in turn leads to localized redness and swelling. Urethritis may also cause frequent urination, urinary urgency, urinary pain and other symptoms, which can be treated with amoxicillin capsules, azithromycin tablets and other medications under the guidance of a doctor. 2. glans: usually due to the glans cleaning is not in place the accumulation of foreskin scale, foreskin scale will stimulate the foreskin and the head of the penis, which in turn leads to the phenomenon of redness and swelling of the urinary orifice. Glans may also have skin erosion, bleeding, pain and other symptoms, which can be treated with drugs such as levofloxacin hydrochloride capsules and fluconazole capsules under the guidance of a doctor. In daily life, patients should pay attention to rest, avoid overwork, keep local skin clean, avoid all kinds of stimulation. Discomfort should be timely to the hospital, clear cause, under the guidance of the doctor, avoid unauthorized use of drugs.