The survival time of patients with second recurrence of breast cancer is related to their timely treatment or not, how effective the treatment is, the severity of tumor recurrence, the patient’s psychological ability, etc. Those with ideal treatment can survive for 1-3 years. The chance of recurrence within 5 years after breast cancer surgery is relatively high, especially 3 years after surgery. The specific recurrence is considered according to the staging and staging of breast cancer. For example, in breast cancer staging, hormone receptor-positive recurrence is later and triple-negative recurrence is earlier. Once breast cancer has recurred and metastasized, it may not be completely cured, but it can be treated accordingly to achieve the purpose of prolonging the patient’s survival time and improving the quality of survival. Patients with second recurrence of breast cancer should relax their mind, maintain a good living environment and mood, and proactively cooperate with doctors for treatment.