Topical use of IOP-lowering eye drops in children may affect or damage the ocular surface system, and may also affect conjunctival cup cells and conjunctival epithelial cells, generally more significantly the longer they are used. Since the eye drops contain preservatives in varying concentrations, they can have a significant damaging effect on the ocular surface cells, as well as the ocular surface tear film. If patients use preservative-containing eye drops for a long period of time, it may cause toxic damage to the tear film stability and corneal epithelium, causing tear film instability and corneal epithelium toxicity, causing patients to experience conjunctival congestion, eye stinging and other uncomfortable symptoms. Long-term use of eye drops may also have an effect on the patient’s conjunctival cup cells and conjunctival epithelial cells, and may affect the formation of healthy filtering vesicles if the patient undergoes anti-glaucoma surgery. It is recommended that children with elevated intraocular pressure (IOP) be seen promptly for evaluation of their condition and treatment as prescribed by their physician.