A large pressure difference usually allows you to take antihypertensive medication. The difference between systolic and diastolic blood pressure values greater than 60mmhg is usually called increased pulse pressure, and is commonly seen in the elderly with systolic hypertension. At this time, as long as the systolic or diastolic blood pressure in any of the blood pressure value reaches the standard of hypertension, can be diagnosed as hypertension, generally need to take antihypertensive drugs for treatment. Clinically normal adults in a quiet state, the normal value of blood pressure is 120/90mmhg, if the average value of blood pressure measured for three times not on the same day is more than 140/90mmhg, then it can be diagnosed as high blood pressure. Usually there is a difference between the systolic and diastolic blood pressure, which is called differential pulse pressure. Usually, hypertensive patients with differential pulse pressure can be treated with blood pressure-lowering drugs such as hydrochlorothiazide, metoprolol, elapril and nifedipine. It can reduce the extracellular volume and lower the peripheral vascular resistance through sodium excretion to achieve the level of blood pressure reduction. Secondly, they can control myocardial contractility and slow down the heart rate to lower the blood pressure. If the difference in pulse pressure between three measurements taken on a different day is large, it is recommended that you consult a cardiovascular physician in time to treat your condition.