Soreness and fatigue may be caused by overexertion, upper respiratory tract infection, osteoporosis, etc. Physiotherapy, medication and surgery can be chosen according to different causes. 1. Overwork: Excessive exercise can lead to muscle fatigue, causing excessive lactic acid secretion, which leads to body aches and fatigue. It is recommended that the patient to strengthen the rest, through the movement of stretching, with massage, hot compresses to promote lactic acid absorption, subside, so as to alleviate the symptoms. 2. Upper respiratory tract infection: This disease can be accompanied by headache, fatigue and limb pain. Patients need to prevent cold and drink a lot of water, headache, fever, generalized muscle pain and other symptoms can be prescribed the use of antipyretic and analgesic drugs, such as acetaminophen, aspirin, ibuprofen and so on. 3. Osteoporosis: clinically, it mainly manifests as weakness, back or limb pain, spinal deformity or even fracture. Patients can choose calcium carbonate, calcium citrate and other calcium supplements. Common drugs for clinical treatment of osteoporosis include salmon calcitonin, zoledronic acid, alendronate sodium and so on. If osteoporosis leads to fracture, surgery is needed as soon as possible. If you do not feel better after resting or applying hot compresses, it is recommended that you consult a doctor to determine the cause of the disease and then follow the doctor’s instructions.