Coffee spots usually do not need medication or surgery, and topical ointment cannot lighten coffee spots. Coffee spots are mainly treated with laser therapy, such as Q laser and intense pulsed light. The cause of coffee spots is still unclear, and some studies in the medical field believe that the appearance of coffee spots is related to genetic factors and abnormal signaling pathways that control skin deposits. Café-au-lait spots may appear at or shortly after birth, and usually do not cause other uncomfortable symptoms. Coffee spots usually do not require special treatment, but can be treated with Q laser if they affect the appearance. Through the principle of selective photothermal effect, it releases huge pulse energy to smash melanin particles and promote the metabolism and absorption of pigment particles so as to lighten the color spots. To sum up, drug treatment can not play the role of lightening coffee spots. Patients with treatment hospitals are recommended to go to regular hospitals for dermatology consultation and standardized treatment with doctor’s advice.