Untreated advanced prostate cancer can lead to the development of the disease, and the survival rate will be reduced, usually no more than six months. The specific actual survival time is related to the individual’s physical condition, disease progression and other factors. It is recommended that patients with advanced prostate cancer undergo regular treatment as early as possible. For patients with advanced prostate cancer who have metastases, the survival time is usually 3~4 years. Some patients, through active and effective treatment, can survive for 5~10 years with a significantly longer overall survival rate than those who are on watch and wait, but patients who are untreated have a shorter survival period, usually no more than half a year. Patients with advanced prostate cancer may have symptoms such as pain at bone metastasis sites, difficulty in urination, swelling of lower limbs, hematuria, hemoptysis and so on. At present, the treatment methods for advanced prostate cancer include chemotherapy, new targeted therapy, radionuclide therapy, etc. Through active treatment, patients can improve their prognosis, prolong their life and reduce pain. Generally speaking, the earlier the disease is detected, diagnosed and treated, the less the impact of the disease on life expectancy. Patients with advanced prostate cancer should maintain a healthy mindset and good emotions, actively cooperate with doctors to maximize clinical efficacy, and not give up on themselves.