The skull is a very important bone in our head, it is the barrier between our brain and the outside world, protecting the normal operation of the brain tissue. The skull may be defective due to many reasons, such as accidental fall from height, injury by heavy objects that may cause brain damage, or the skull itself requires debridement surgery due to lesions, thus causing the defect of the skull. Skull defect will be very harmful, can not make the brain tissue get a good protection, thus affecting the normal operation of the human body, and long-term will make patients have a great psychological barriers, because the brain collapse or expansion of their own different from ordinary people, resulting in low self-esteem, lack of self-confidence, thus greatly affect the life and work of patients. Therefore, patients with large skull defects should undergo skull repair surgery as soon as possible within three months after surgery. Of course, the repair material is also very important, some repair materials can also cause side effects after the repair, the most widely used titanium mesh, some patients will have rejection or other side effects after the use, so patients should also carefully choose the repair hospital and materials. At present, some hospitals are using a new material for patients to carry out cranial repair, polyether ether ketone material is commonly known as peek material is currently the most ideal repair material recognized by many experts, in use since, many patients with cranial repair have carried out repair surgery through peek material, and after long-term follow-up found that the basic recovery after surgery is very good.