A common cause of blisters in the cracks of the feet is tinea pedis, which needs to be treated with antifungal medication. Tinea pedis is a skin disease of the feet caused by fungal infections that occur between the toes and on the soles of the feet. Patients can follow the doctor’s instructions to use miconazole, naftifine ketoconazole, amorolfine and other drugs in the local topical application. If the effect of local treatment is not good, recurrence of people, can be prescribed oral itraconazole, terbinafine and other antifungal drugs. Combined use of drugs can enhance the therapeutic effect. When small blisters appear in the foot seam, you should consult a doctor in time to make a clear diagnosis and give appropriate treatment. In addition, patients should not squeeze the small blisters, so as not to induce infection.