Stomatitis is a general term for inflammation that occurs at the union of the upper and lower lips, with chapping, corners of the mouth erosion and crusting as the main symptoms. Stomatitis is an inflammatory reaction in the area of the corners of the mouth that affects speech and eating, and medication for stomatitis needs to be based on the cause. The common causes of stomatitis are malnutrition or vitamin and trace element deficiency, especially vitamin B2; it can also be caused by systemic factors such as diabetes and anemia; infections are also common: caused by pathogenic microorganisms such as bacteria, viruses and fungi, most commonly caused by Candida albicans, Staphylococcus aureus and Streptococcus. The treatment for different causes of stomatitis is different. Malnutrition keratitis should be given appropriate medication according to its cause, such as vitamin supplementation, folic acid, etc. to treat systemic diseases, and can be treated locally with 0.1% ezacridine lactate wet compresses, coated with povidone iodine or antibiotic ointment. Stomatitis due to bacterial infection can be treated with topical antibiotics, such as aureomycin ointment or erythromycin ointment applied topically. Fungal keratitis can be treated with topical miconazole cream or clotrimazole ointment. For herpes virus-induced stomatitis, antiviral medications such as acyclovir ointment should be used. For specific medication, please refer to the clinical situation and follow the guidance of the doctor’s interview.