LDL 5.38mmol/L is significantly higher than the normal range and is considered serious. LDL is one of the risk factors for atherosclerosis, at ≤3.12mmol/L is considered appropriate level, greater than 3.64mmol/L is considered to be elevated, 5.38mmol/L is significantly higher than the normal range, so it is considered to be serious and need treatment, the treatment program mainly includes medication, improve the lifestyle, appropriate exercise and so on. Increased LDL can be used to determine the risk of coronary heart disease, can also be seen in hypothyroidism, nephrotic syndrome, hereditary hyperlipoproteinemia, cholestatic jaundice, obesity and the application of a drug. If LDL 5.38mmol/L, please go to the hospital in time to find out the cause of the disease and targeted treatment, do not blindly use drugs, so as not to delay the condition.