A Ki-67 of 30% cannot determine whether it is early stage. Staging of malignant tumors needs to be based on the primary tumor, lymph node metastasis and distant metastasis. Ki-67 is a protein expressed in the nucleus of cells, and its expression is related to the activity of cell division, which is not necessarily related to cancer staging. ki-67 is closely related to the cell division cycle, and the higher percentage of ki-67 suggests that the tumor cells are more active in proliferation and division, so ki-67 can be used to judge the prognosis of cancer patients and assess the degree of malignancy of tumors, Currently, the main indicators of cancer staging include primary tumor, lymph node metastasis, and distant metastasis: T refers to primary tumor, N refers to lymph node metastasis, and M refers to distant organ metastasis. According to different TNM staging combinations, the clinical staging of patients can be derived, which in turn guides the next step of treatment.