Waking up with body aches and weakness may be due to over fatigue, osteoporosis, infectious diseases, poor sleep quality, as follows: 1, over fatigue, this situation is most common, often seen in the previous day to do high-intensity labor or excessive exercise, which leads to over fatigue in many muscles and tendons throughout the body, in the patient will appear after a night of rest, body aches and weakness; 2, osteoporosis, often in the elderly is more common. Once severe osteoporosis occurs, the patient will often wake up with general weakness and soreness in the bones and joints of the body; 3. The above-mentioned conditions may lead to muscle tension in the whole body during sleep, followed by weakness and pain after waking up.