It is not recommended to take progesterone after drinking alcohol, because progesterone is an acidic drug, and taking progesterone after drinking alcohol will lead to an increase in stomach acid. After drinking alcohol will cause acid reflux and heartburn, especially for patients with previous gastric disease, chronic gastric ulcer, chronic gastric atrophy or for patients with bile reflux gastritis, taking progesterone after drinking alcohol is particularly likely to cause nausea, vomiting and other symptoms of gastric mucosal erosion and irritation, and in more serious cases, there will be adverse reactions of upper gastrointestinal bleeding. The ethanol and acetaldehyde in alcohol will react with the active ingredients of progesterone after drinking, and taking progesterone after drinking will cause reactions such as secondary failure of the drug. In addition, some substances in progesterone can also cause allergic reactions, which can lead to itchy skin and discomfort around the body, so it is not recommended to take progesterone after drinking.