Parkinson’s syndrome leg weakness and stiffness of patients, can consider oral levodopa or pramipexole and other drugs treatment. Parkinson’s syndrome leg weakness and stiffness of the patient is considered to be due to the emergence of muscle ankylosis caused by leg activity disorders, check the patient’s limbs, neck muscles, can be felt to have obvious resistance, this resistance presents uniform characteristics, so it is known as lead pipe-like ankylosis. If the patient is combined with tremor of the limbs, intermittent pauses in the uniform resistance, cogwheel-like ankylosis can occur. If the patient is older (65 years of age or older), he or she may be treated directly with oral levodopa. If the patient is younger (under 65 years of age), the patient may be treated with oral dopamine agonists such as pramipexole. The above medications, need to be used under the supervision of a doctor to minimize possible drug side effects such as vertigo.