After a gastroenterology patient’s visit, the doctor often advises: “Be emotionally stable and cheerful”. This phrase may seem like a “medical cliché”, but it is really important. Bad moods can really make your gastrointestinal tract “change its face”. The digestive system, including the esophagus, stomach, small intestine, large intestine, liver, gallbladder and pancreas, is an extremely sophisticated, coordinated and efficient machine, peristalsis, pressure, blood flow, temperature, digestion, absorption, secretion …… Together, they respond to many changes inside and outside the body. It is not good to have any abnormality in any one part or link. The esophagus is only tasked with passage, and emotions such as sadness, anger, and anxiety can narrow or even completely block the lumen of a healthy esophagus and prolong the passage of food and drink. Changes in intraluminal pressure are also associated with emotional state. Clinically, it is seen that people after great sadness complain of posterior sternal blockage, unfavorable lowering of the throat and other symptoms are not unrelated to these changes. Negative emotions affect health. When a person is in hatred, gastric acid secretion increases, blood flow increases, and the mucosa becomes red in color (congestion). At this time, the gastric mucosa is extremely brittle, and even minor, tiny damage can turn into small ulcers, which some believe creates the conditions for H. pylori to “strike”. When depression, helplessness, disappointment and other emotions take over, the secretion of gastric acid decreases. The small intestine becomes more tense as a result of the person’s mood, and a barium meal reveals a prolonged emptying time. The colon appears to be more sensitive. Colonoscopy and wave counting devices have documented the presence of a peristaltic hypermobility state in both healthy and irritable bowel syndrome patients with adverse emotions. In sadness, depression, and disappointment, there is an increase in wave-like tension and increased peristalsis leading to diarrhea. In fear and frustration, the colonic mucosa becomes pale and non-contractile, while in anger, complaints and hostility, the mucosa becomes red and contractile. The gastrointestinal tract is known as the “second brain” The brain is the supreme commander of various physiological activities of the human body, including the regulation of mental and emotional activities, which naturally involves external reactions. It is known that there is a family of peptides in the brain that are closely associated with neural activity in the brain, such as a peptide called TRH that increases in the brain when depressed. Scientists have made two major discoveries after intensive research on the nerves of the gastrointestinal tract One is the discovery of the enteric nervous system. The entire gastrointestinal tract is covered with more than 100 million nerve cells, which are densely distributed from the mucosal layer, the muscular layer to the plasma membrane layer, the total number of which is second only to the brain and is called the “gut brain” or “second brain”. It has its own complete reflex system in the gastrointestinal wall, which, in layman’s terms, can regulate the physiological activities of the stomach and intestines on its own without the command of the “command” of the brain, and can also transmit the disposal process to the “command” and influence the activities of the “command”. The second major discovery is that there are special cells in the intestine that secrete exactly the same peptides as in the brain to complete the various commands of the enteric nervous system, so that the movement, secretion, digestion, pressure and even temperature of the digestive tract can be regulated to adapt to various changes. The peptide hormones in the brain are identical to the peptide hormones in the intestine, which are far away from the brain, thus giving them a general name – brain-gut peptides. In this way, the brain and the gastrointestinal tract not only have “land traffic” – the autonomic nervous system, but also “waterway” – the brain and intestinal peptides. The two are closely connected, not only can give instructions, but also can upload the lower feelings, so it is called two-way channel. Modern people’s work is intense, fast-paced life, heavy mental burden, many people are in a dual physical and emotional subhealth state, in the long run, it is easy to trigger the gastrointestinal tract dysfunction. In recent years, the “bio-psycho-social” medical model promoted by the medical profession has provided a holistic treatment model for functional gastrointestinal diseases. When treating patients with functional gastrointestinal disorders, doctors should understand not only the physical symptoms of the gastrointestinal tract, but also the psychological and social factors that cause gastrointestinal discomfort, so that they can give appropriate treatment. First, to maintain a good psychological state, correctly see the various frustrations and difficulties in life and work. Those who have severe anxiety and depression and other psychological disorders can take appropriate anti-anxiety and anti-depressant drugs under the guidance of doctors. Second, to develop good living habits, do not overwork, do not smoke and alcohol, reasonable adjustment of diet, eat less too sweet, too acidic, too spicy food. Third, if the symptoms of gastrointestinal discomfort are more serious, you can take appropriate gastrointestinal motivation drugs, acid control drugs, etc. under the guidance of a doctor.