The effects and actions of hydrocortisone are anti-inflammatory, anti-allergic, and immunosuppressive. Usage includes oral, intramuscular, intravenous, and intra-articular injection. Hydrocortisone is a kind of glucocorticoid drug, can be used for the treatment of adrenocortical hypoplasia or hypopituitarism and other diseases; at the same time, the drug has the effect of anti-inflammatory, anti-allergy, immunosuppression, etc., so it can be used for the treatment of severe allergic reactions, asthma persistent state, shock, etc. For serious infectious diseases, need to be guided by a doctor to choose whether or not to apply the drug. When hydrocortisone injection is used for the treatment of hypoadrenocorticism, it is necessary to choose the appropriate dose and dosage form for treatment according to the patient’s age, condition or body surface area. The adverse effects of the drug are related to the course of treatment, dosage, type of medication and route of administration, etc. Cushing’s syndrome, concurrent infections, susceptibility to bleeding tendency, and necrosis of the femoral head may occur with prolonged use. Patients should apply hydrocortisone under medical supervision and choose the appropriate dose and dosage form.