Rheumatic diseases include ankylosing spondylitis, rheumatoid arthritis, systemic lupus erythematosus, gout, osteoarthritis and other diseases, which may be hereditary, but there is also a certain relationship with the environment, living habits and other factors, according to the strength of the relationship with heredity is divided into closely related, related to the relationship is weak. 1. Closely related to heredity: Ankylosing spondylitis is a kind of polygenic genetic disease caused by both heredity and environment, 90% of the patients in the morbid population are HLA-B27 positive, presenting the phenomenon of family aggregation of disease. 2. The disease is related to heredity: rheumatoid arthritis, systemic lupus erythematosus is a kind of disease whose exact pathogenesis is unknown, but the research found that the disease has a certain relationship with heredity, for example, there are data indicating that single-foetus twin-ovary people suffering from systemic lupus erythematosus is 5~10 times higher than heterozygous twin-ovary ones. 3. Weak relationship between disease and heredity: such as gout, osteoarthritis and other rheumatic diseases have a relationship with heredity, but relatively speaking, the role is relatively weak, mainly related to diet, work habits and other factors. Rheumatism patients are recommended to the regular hospital rheumatology and immunology department and other related departments for detailed consultation, follow the doctor’s instructions standardized treatment.