There are several reasons for thigh soreness and tenderness, the most common reason is due to muscle strain, such as long walking, running or labor will damage the thigh muscles, thigh muscles in the case of strain, there will be anaerobic fermentation is the production of a large amount of lactic acid inside the muscle, acidic substances, if the accumulation of the muscle layer, it will lead to the thigh muscles have a noticeable soreness and tenderness of the sensation. After this feeling, after normal rest can let the lactic acid metabolism and relief, but also can take alkaline drugs for treatment can play a good role. Some people appear thigh muscle soreness, tenderness is often caused by diseases, such as rheumatoid arthritis, rheumatoid arthritis and other diseases, will lead to muscle pain and other conditions. For older, weaker patients with chronic diseases, there will be thigh muscle soreness, tenderness, to be able to relieve through proper rest and nutritional regimen.