If a patient is found to be positive for H. pylori on examination, the saliva may also contain H. pylori. H. pylori is a bacterium that parasitizes the human stomach. After being infected with H. pylori, H. pylori will also be found in the patient’s saliva, so H. pylori can be transmitted through the oral-oral route (e.g., kissing, eating together, feeding, etc.) and the fecal-oral route, which makes it easy to form a cross-infection in the family. H. pylori infection is closely related to the occurrence of chronic gastritis, peptic ulcer, gastric cancer and other diseases, once found positive in the examination, eradication treatment should be carried out in a timely manner. During the treatment period, attention should be paid to sharing meals with family members and avoiding sharing a set of tableware to avoid cross-infection. Patients who are positive for Helicobacter pylori are advised to seek timely medical attention and actively receive treatment to avoid delaying their condition.