The extent of lesions with pathomorphologic changes in the glomeruli varies widely. Early lesions are mild and focal, only a few glomeruli have mild thylakoid widening and staged hyperplasia, and focal proliferative changes may progress to focal sclerosis. Some lesions are more pronounced and may have diffuse thylakoid hyperplasia and occasionally crescent formation. The most striking feature is immunofluorescence showing lgA deposition in the thylakoid region with concurrent C3, less lgG and IgM, and electron microscopic observation confirming electron-dense material deposition in the thylakoid region. Here is how to effectively prevent the glomerulus from having pathological morphological changes. 1, work and rest combination Because of overwork, strenuous exercise, often can make the hematuria increase, so should be to live in moderation, pay attention to bed rest, moderate exercise, to prevent staying up late, overwork and strenuous exercise. 2, prevention and control of inflammatory diseases Actively eliminate susceptible and triggering factors, such as upper respiratory tract, skin, intestinal and urinary tract infections, eradication of sores, fungal infections, tonsillectomy is feasible for those who repeatedly develop hematuria due to tonsillitis, and circumcision is appropriate for children with overcircumcised foreskin. Once the inflammatory infection appears, actively treat it. 3, mental conditioning All patients suffering from blood in urine have varying degrees of mental tension, depression and pessimism. Therefore, in daily life, we should pay attention to words and deeds, panic, shouting, etc. will increase the patient’s anxiety and fear, so mental conditioning is particularly important. As far as possible to reduce the adverse mental stimulation of the patient, to maintain a relaxed mood, in order to facilitate the recovery of the disease. 4, prevention of exopathic The disease is often aggravated by upper respiratory tract infection, tonsillitis, so the cold should be prevented, such as poor health, easy to catch a cold, moderate exercise to increase resistance, to prevent on call. 5, prevention of renal insufficiency There are many factors affecting the long-term prognosis of IgA nephropathy, most commonly in elderly men with the onset of the disease, or persistent hematuria with a large amount of proteinuria, or patients with severe hypertension, etc. In such cases, close observation should be made, great attention should be paid, and timely and reasonable protective measures should be given, so that the development of IgA nephropathy to renal failure can be stalled and the purpose of treatment and prevention of change can be achieved.