PH leukemia refers to PH chromosome-positive leukemias, including chronic granulocytic leukemia (CML), some acute lymphoblastic leukemias (ALL), and a few acute myeloid leukemias (AML). The PH chromosome refers to the combination of the proto-oncogene abl translocation on the long arm of chromosome 9 to the bcr gene on chromosome 22, which combines to form a fusion gene. Overexpression of this fusion gene activates downstream signaling pathways and initiates cell proliferation, leading to the development of chronic granulocytic leukemia.PH chromosome positivity can be seen in 95% of CML, some ALL and a small number of AML, and can be used as a diagnostic basis for CML. 1. Chronic granulocytic leukemia is a malignant clonal disease of hematopoietic stem cells, mainly involving the myeloid lineage, and its course is generally divided into chronic phase, accelerated phase and acute phase. The chronic phase may be asymptomatic or with symptoms such as low fever, malaise, excessive sweating, weight loss, increased white blood cell count, positive PH chromosome, etc. The treatment drugs include imatinib, lumefantrine, lumefantrine, lumefantrine and lumefantrine. Therapeutic drugs include imatinib, dasatinib and so on. 2. Acute leukemia includes acute granulocytic leukemia and acute lymphoblastic leukemia. At the onset of acute leukemia, abnormal primitive cells and naive cells in the bone marrow proliferate in large quantities and inhibit normal hematopoiesis, which can widely infiltrate various organs such as liver, spleen and lymph nodes. The manifestations are bleeding, anemia, infection and infiltration phenomenon. Therapeutic drugs include cytarabine, Zoerythromycin, vincristine, cyclophosphamide and so on. If PH chromosome positivity occurs, one should go to a regular hospital in time to receive diagnosis and treatment under the guidance of a physician.