Children with high fever is usually not recommended to do “rectal enema”, can be given under the guidance of a physician to correctly give antipyretic drugs, if necessary, can be given rectally, at the same time need to clarify the cause of fever and treatment. Children with fever do rectal enema usually refers to the saline or drugs (such as dexamethasone) to be anorectal administration, the drug absorbed through the anorectal mucosa and then play a role, such methods of drug dosage and drug play time are not clear, and easy to cause local mucosal damage secondary infection, therefore, it is not recommended to use such methods. For children with high fever, it is recommended that the appropriate dose of antipyretic medication (e.g., ibuprofen or acetaminophen) be given under the direction of a physician, depending on the child’s weight, to reduce fever and to closely monitor the degree of decrease in body temperature. If necessary, anally administered medications can be used under the direction of a physician. At the same time, the cause of the fever should be clearly identified and actively treated, such as influenza, children may have a high fever, generalized malaise and other manifestations of the treatment need to be oral oseltamivir phosphate treatment. For children with Kawasaki disease, the above symptoms can also occur, accompanied by skin rash, hard swelling of the hands and feet, conjunctival congestion, etc., the treatment requires intravenous infusion of gammaglobulin and oral aspirin and other medications. Children with high fever should consult a doctor in time to clarify the cause of the disease, and strictly follow the doctor’s instructions to use medication, do not self-medication.