High estrogen levels can be antagonized by progesterone, androgens, and can also be regulated by oral GnRHa drugs. Estrogen is the hormone that maintains female secondary sex characteristics, promotes endometrial proliferation, and maintains normal menstrual cycle and ovulation. However, too much estrogen can lead to excessive endometrial hyperplasia, which can result in dysfunctional uterine bleeding, ovulation disorders, endometriosis, ovarian and breast lesions, and so on. In case of endometriosis or endometriosis, a large amount of progesterone can be used as prescribed by the doctor, such as pregnentrienolone and methylhydroxyprogesterone can be used to inhibit endometrial hyperplasia, and testosterone propionate and methyltestosterone can be taken orally by patients over 40 years of age, but long-term use is not recommended. Excessive estrogen levels require prompt medical attention and treatment under the guidance of a doctor.