High white blood cells with normal C-reactive protein is a clinically common condition; C-reactive protein is a sensitive special protein that occurs in stressful situations and has a high sensitivity and low specificity. First, infection is a common cause. Second, it is a stressful situation, including fever, because the body is under stress, which can also lead to an increase in leukocytes. Thirdly, the increase of leukocytes is mostly seen in the abnormal hematopoietic function of bone marrow, including leukemia, myelodysplastic syndrome and the use of leukocyte-raising drugs, which can lead to an increase of leukocytes. Therefore, it is quite common to have high white blood cells and normal C-reactive protein. We have to analyze the specific problem and assess the degree of leukocyte elevation, and then administer medication according to the degree of elevation to clarify the cause.