AST is alanine aminotransferase and ALT is alanine aminotransferase, both of which are mainly found in hepatocytes and are important indicators of liver cell damage. When the liver function is abnormal, the ratio will be high, which may be caused by physiological factors and pathological factors, according to the different situations, use different drugs to treat. 1. Physiological factors: such as drinking a lot of alcohol, overwork, strenuous activities and other factors. It is necessary to pay attention to alcohol cessation, eat a light diet to reduce the metabolic burden on the organs. 2. Pathologic factors: (1) Liver failure: a high ratio of AST and ALT indicates a long-lasting and serious condition, suggesting massive necrosis of liver cells. Hepatoprotective and enzyme-lowering drugs such as silymarin and glycyrrhizic acid preparations can be used. (2) Viral hepatitis: such as hepatitis B, hepatitis C, etc. can also lead to high AST and ALT ratio, need to use antiviral drugs such as interferon, tenofovir, etc. to inhibit the replication of the hepatitis B virus and slow down the development of liver fibrosis and cirrhosis. It is recommended that the use of drugs should be carried out under the guidance of a physician, the occurrence of elevated ratio should be timely to the hospital for relevant examinations to clarify whether there is a related organic liver disease. Avoid taking drugs that impair liver function.