Diarrhea and fever may or may not be the result of a novel coronavirus infection. Patients should undergo prompt nucleic acid testing. If the test result is positive, it is considered to be due to novel coronavirus infection. If the test result is negative for nucleic acid test, it may be caused by acute gastroenteritis or gastrointestinal cold. Patients with novel coronavirus infection may have no obvious symptoms in the early stage, but some patients may have fever, diarrhea, malaise, muscle pain and other symptoms. However, it is not possible to determine that it is a novel coronavirus infection by symptoms. Patients need to undergo a nucleic acid test, and if the result of the nucleic acid test is positive, it may be infected with a novel coronavirus, and if the result of the nucleic acid test is negative, it is not due to a novel coronavirus infection. The patient’s symptoms of diarrhea and fever may also be caused by acute gastroenteritis, as acute gastroenteritis can have symptoms such as fever, nausea, diarrhea, loss of appetite, and vomiting. In addition, patients may have diarrhea and fever due to gastrointestinal flu with fever, vomiting, and diarrhea. Symptoms of diarrhea and fever in patients may be caused by novel coronavirus infection or other diseases. It is recommended that the patient seek medical attention to identify the cause of the disease and follow the doctor’s instructions for treatment.