A warning to all friends, soon after the New Year holidays, taking antibiotics during (not only cephalosporins, metronidazole class), absolutely no alcohol! No alcohol! Otherwise there will be disulfiram-like reactions, heartbeat suppression, increasing the risk of sudden death! The consequences are unthinkable! Recently, some media friends asked me to verify this crazy news in the circle of friends, my opinion is: “This message is true, in addition to the message mentioned cephalosporin, metronidazole, but also pay attention to other drugs that fall on the wine.” It’s almost New Year’s Eve, and all kinds of parties and social gatherings are starting to become more frequent, so today I’d like to talk to all my friends about the drugs that make you fall down when you get drunk. What is a disulfiram-like reaction? Disulfiram-like reactions are facial flushing, conjunctival congestion, blurred vision, severe pulsating head and neck vessels or pulsating headache, dizziness, nausea, vomiting, sweating, dry mouth, chest pain, myocardial infarction, acute heart failure, respiratory distress, acute liver injury, convulsions and death if alcohol is consumed after the drug is administered. On examination, there may be a decrease in blood pressure, an accelerated heart rate (up to 120 beats/min) and normal or partially altered ECG (e.g. ST-T changes). What drugs can cause disulfiram-like reactions? 1.Cephalosporins Cefoperazone, cefoperazone sulbactam, ceftriaxone, cefazolin (Pioneer V), cefradil (Pioneer VI), cefmetazole, cefmetazole, cefminox, cephalexin, cefamandole, cefamandole, cefadroxil (Pioneer IV), cefaclor, etc. in cephalosporins. 2.Nitroimidazole drugs such as metronidazole (methotrexate), tinidazole, ornidazole, Secnidazole. 3, other antibacterial drugs such as furazolidone (dysentery), chloramphenicol, ketoconazole, ashwagandha, sulfonamides (sulfamethoxazole), etc.. Among them, cefoperazone causes the most reports of disulfiram-like reactions and is the most sensitive. In order to prevent disulfiram-like reactions, all patients applying cephalosporins should be routinely asked whether they have a history of drug allergy, alcohol allergy and recent history of alcohol consumption, and if the patient has a history of alcohol consumption 7 days before the drug is used, the drug should be prohibited, and the patient should be instructed to abstain from alcohol for no less than 7 days after stopping the drug. In the event of a disulfiram-like reaction, the drug should be discontinued immediately and the appropriate measures should be taken. If a patient eats chocolate with alcohol, takes patchouli, or even treats the skin with alcohol alone after using these drugs, a disulfiram reaction may occur. What should I do if I have a disulfiram reaction? Once a disulfiram-like reaction occurs, the drug and alcohol-containing products should be discontinued promptly.