Urine protein is an independent risk factor for renal failure, and the presence of any degree of positive urine protein should be taken seriously and alerted. Two plus signs of urine protein do not reflect the severity of kidney disease, but need to be combined with 24-hour urine protein quantification, kidney function, kidney ultrasound and other tests to comprehensively assess the severity of the patient. If the patient’s 24-hour urine protein quantification is not very high, but there is an increase in blood creatinine and urea nitrogen, and the volume of both kidneys is reduced, it indicates that the urine protein lasts for a long time, the glomerulus has been sclerotic, and the condition is relatively serious. However, if the urine protein appears within a short period of time, the kidney function is normal, and the kidney volume is normal, it indicates a relatively mild condition. The severity of positive urine protein caused by secondary kidney disease is related to the progression of the primary disease and its treatment. If the primary disease is heavy, the condition will be relatively severe even if the urine protein is not very high, so whether the urine protein two plus is serious should be comprehensively analyzed and comprehensively evaluated.