Symptoms of unexplained childhood hepatitis are mainly characterized by jaundice and gastrointestinal symptoms (e.g., decreased appetite, nausea and vomiting). In acute hepatitis in children with unknown causes, jaundice is caused by liver damage, which reduces the uptake and processing of indirect bilirubin, as well as swelling of the liver cells, which prevents the hepatic bile ducts from discharging bile. In addition, since the liver is a digestive organ, damage to the hepatocytes can lead to gastrointestinal symptoms such as loss of appetite, nausea and vomiting, abdominal pain, and diarrhea in the affected child. Hepatocellular damage can also lead to elevated alanine aminotransferase (ALT) and aliquot aminotransferase (AST) on liver function tests. Unexplained acute hepatitis in children is predominantly found in children between the ages of 1 month and 16 years, with children under the age of 10 years being susceptible to the disease.