Cold pain in the knee is mostly caused by wind, cold and dampness, which belongs to the symptoms of pain paralysis, and should be prescribed by a professional physician, commonly used drugs such as aconite soup. Pain paralysis is often manifested as joint pain in the limbs, pain is more severe, the pain has a fixed place, joint flexion and extension of unfavorable, the local skin or a cold feeling, cold pain is very cold, the pain is reduced by heat, the mouth is pale, thirst, evil wind cold, etc., the treatment should be warming the cold, dispel the wind and remove dampness, the formula for the aconite soup. In the formula, aconite drives away cold and dampness; ephedra passes yang to paralyze; peony and licorice open the paralysis and pass the blood, so that yin and yang can be declared through and the qi and blood can flow freely; astragalus is a real guardian (produced by the essence of water and grain, its main function is to guard the surface of the muscle and resist the invasion of external evils) and prevents ephedra from dispersing too much; white honey is a sweet and slow medicine to relieve the cold and dampness of the evils of the sweat and to reduce the toxicity of aconite. The adverse effects and contraindications of this formula are not clear. After discomfort occurs, one should consult a doctor and choose medication under the guidance of physician’s diagnosis, and should not use medication on one’s own in order to avoid delaying the condition.