Prolapse, or rectal prolapse, refers to a condition in which the rectum of the anal canal prolapses outside the anus due to exenteration. Gastrointestinal dilatation with prolapse is seen in some patients with elastic pseudoxanthomatosis. The dilatation is caused by gas accumulation in the stomach and intestines due to abnormal digestive function. The disease is a systemic elastic fiber disorder, the cause of which is unknown to date. Most people believe that it is related to congenital factors. Therefore, the prevention of gastrointestinal dilatation and prolapse should refer to the prevention methods of genetic diseases. In addition to the epidemiological survey, carrier detection, population genetic and environmental guardianship, marriage and fertility guidance from the perspective of the whole population, efforts to reduce the incidence of genetic diseases in the population and improve the quality of the population, effective preventive measures must be taken for individuals to avoid the birth of offspring with genetic diseases (i.e., practice eugenics) and The usual measures include premarital examination, genetic counseling, prenatal examination and early treatment of genetic diseases. Premarital examination: Premarital examination (i.e. marriage health care) is an important part of ensuring a happy life and healthy offspring for both men and women after marriage. The focus of premarital examination is: ① genetic disease investigation, including detailed inquiries into the health status of men and women and their family members, past medical history and treatment, especially the presence of congenital malformations, history of genetic diseases and history of consanguineous marriage. If necessary, a family survey, blood type examination, chromosome examination or genetic diagnosis should be conducted to detect carriers; ② comprehensive physical examination, mainly for acute infectious diseases, tuberculosis, or serious heart, liver and kidney diseases, chronic inflammation of the urinary tract and other diseases that can seriously threaten the health of the individual or spouse, as well as the detection of severe anemia, diabetes and other diseases that can affect the fetus in the female partner, and mobilize only after cure (3) Examination of male and female reproductive organs to detect malformations of sexual organs, gender anomalies and other disorders so that early measures can be taken. Genetic counselling: Genetic counselling is a genetic counselling service provided by a clinician to answer questions from patients with genetic diseases and their relatives about the cause, mode of inheritance, diagnosis, treatment and prognosis of genetic diseases, to estimate the probability of the patient’s children suffering from a certain disease, and to provide advice and guidance for the patient and his relatives. The significance of genetic counseling is to: ① alleviate the physical and mental pain of patients, reduce the psychological pressure of patients and their relatives, help them treat genetic diseases correctly, understand the probability of incidence, and take correct preventive and therapeutic measures; ② reduce the incidence of genetic diseases in the population, reduce the frequency of harmful genes, and reduce the chance of transmission. Prenatal diagnosis: Prenatal diagnosis, also known as intrauterine diagnosis or antenatal diagnosis, is the detection of the sex and health status of the fetus during pregnancy in order to take the necessary measures to prevent the birth of children with genetic diseases or congenital malformations. Prenatal diagnosis is a process of biochemical genetics, genetic testing and health testing. Prenatal diagnosis is the product of the combination of biochemical genetics, cytogenetics, molecular genetics and clinical practice. The development of high-resolution banding technology, genetic engineering technology, as well as villi aspiration and culture technology, has made the application of prenatal diagnosis more extensive and the results more accurate.