Colon with localized adenohigh-grade neoplasia with clean margins is usually curable. Colon with localized supratentorial hyperplasia is a precancerous lesion, which can be treated with complete surgery in the early stage, and generally can achieve the goal of clinical cure. Colon with localized supraglandular high-grade neoplasia belongs to severe atypical hyperplasia, which is a precancerous lesion of colon cancer and requires prompt surgical treatment. If not controlled, it may develop into a malignant tumor. At present, enteroscopic mucosal debulking surgery is mostly used in clinic. After surgery, we need to try to avoid risk factors, such as bad living habits, environmental factors, etc., and try to eat a light diet, avoiding spicy and stimulating food, so as to avoid recurrence and deterioration. After surgery for colon with localized adenohypophyseal neoplasia, patients need to undergo regular checkups to avoid recurrence, and early detection and early treatment. Patients with discomfort symptoms need to consult a doctor in a timely manner, improve the examination, under the guidance of the physician active treatment, to avoid deterioration of the situation.