Side effects may occur when using fluconazole and itraconazole to treat disease, as to which side effects are greater varies from person to person, there is no specific data to support a generalization. Fluconazole is indicated for the treatment of coccidioidomycosis, invasive candidiasis and for the prevention of recurrence of oropharyngeal or esophageal candidiasis in patients with cryptococcal meningitis at high risk of recurrence and in HIV (human immunodeficiency virus) infected patients at high risk of recurrence. Contraindicated in patients with hypersensitivity to this product or other azoles, pregnant and lactating women. Adverse reactions such as nausea, vomiting, abdominal pain, diarrhea, rash, exfoliative dermatitis, transient elevation of serum aminotransferase, dizziness, headache, transient neutropenia and thrombocytopenia may occur with the use of fluconazole. When adverse reactions occur, patients are advised to discontinue the drug and seek medical attention. Itraconazole is indicated for the treatment of dermatomycosis, onychomycosis, systemic aspergillosis, candidiasis, and biphasic fungal diseases caused by sensitive genera. It is contraindicated for those who are allergic to the product, pregnant and lactating women, and those with severe hepatic or renal insufficiency. Adverse reactions such as abdominal pain, diarrhea, granulocytopenia, hyperglycemia, hyperkalemia, dizziness, somnolence, heart failure, left ventricular failure, tachycardia, hypertension, jaundice, hyperhidrosis, fever, pain, and elevation of alanine aminotransferase can occur with the use of itraconazole. When adverse reactions occur, patients are advised to discontinue the drug and seek medical attention. If you need to use fluconazole and itraconazole patients, it is recommended to go to a regular hospital, follow the doctor’s instructions to use drugs, avoid blind use of drugs.