Hereditary spherocytosis is an inherited hemolytic anemia with abnormal red blood cell membranes. The disease is inherited from both men and women and occurs in every generation, also known as “autosomal dominant”. The age of onset and severity of the disease varies widely, with most cases occurring in early childhood and children. If the disease develops in newborns or infants under the age of 1 year, the disease is usually severe and often depends on blood transfusions to maintain life. Splenectomy has been shown to be remarkably effective for this disease. The enlarged spleen Suspension of the spleen Exposure of the splenic hilum Exposure of the splenic artery and splenic vein Separation of the splenic artery Ligation of the splenic artery Dissection of the splenic hilum Bagging of the specimen Postoperative incision The child in this case had symptoms since birth, mainly anemia, jaundice, fatigue, malnutrition and growth retardation. He was diagnosed with hereditary spherocytosis after a long period of blood transfusion at the local hospital every one and a half months. At the follow-up visit in one month after the operation, the anemia and jaundice disappeared, and the mental, physical and nutritional conditions improved significantly, achieving a very good outcome.