For hepatitis B patients with liver spots on the face, it is usually caused by the increase of melanin in the body, which leads to facial pigmentation. This situation requires patients to regularly review hepatitis B DNA, hepatitis B three systems and liver function to see whether there is any replication of the virus and whether there is any damage to liver function. If liver function is impaired, liver-protective drugs should be given intravenously or orally in a timely manner, and liver-protective support should be given. If the patient’s virus is replicating, active antiviral therapy is usually required. For hyperpigmentation, in addition to protecting liver function, taking rest, avoiding alcohol, and avoiding exertion, patients can consider going to the aesthetic department of a regular medical institution for phototherapy or blue light irradiation, which is generally effective for hyperpigmentation or skin color changes due to jaundice.