Patients usually need hemodialysis by the time they reach uremia, at which point they are no longer staged, as uremia itself is the end stage of chronic kidney disease, which can be professionally divided into five stages. During this period, patients will have many systemic symptoms, such as nausea, vomiting, inability to eat food, and even gastrointestinal bleeding, and some patients are severely anemic, or exhibit edema of the eyes, face, and both lower limbs, and some patients are even highly edematous, producing ascites Some patients even show edema of the entire lower body, upper body, back or skin of the whole body. Some patients also have symptoms of scanty or absent urine, and some patients may have severe itching of the skin, or even more skin rashes caused by uremic toxins, and some patients may also have brain damage, such as mental disorders, coma, and convulsions. Overall, uremia, the end stage of chronic renal failure, is already advanced, so uremia is no longer staged.