Nodules on the areola may be caused by increased estrogen and progesterone levels, breast nodules and nipple eczema-like breast cancer. 1. Increased estrogen level: When the patient is in puberty or menstruation, due to increased estrogen level or decreased ratio of androgen to estrogen, the subcutaneous glands of the areola are enlarged and hypertrophied, showing nodular changes and forming small bumps, which usually do not need special treatment. 2. Mammary hyperplasia: it may be the nodule formed by breast hyperplasia, benign may be larger, mostly manifested as breast swelling and pain aggravated by menstruation, and disappeared after menstruation. 3. Nipple eczema-like breast cancer: Early patients with nipple eczema-like breast cancer mainly have the skin of nipple areola, itching or burning pain, with the development of the disease, it will be manifested as the symptom of vesiculation at the areola, and even nodules will appear. In addition, breast trauma, breast cysts, mastitis, breast fibroadenoma may also appear similar manifestations, when the patient appears to grow nodules on the areola, it is recommended to go to the hospital in time for examination, to clarify the cause of the disease and then under the guidance of the doctor for medication.