Soft tissue swelling of the outer ankle may be caused by infection, may be caused by aseptic inflammation, may also be caused by trauma, different causes of different drugs can be taken, according to the cause of the clinic can be given amoxicillin and other antibacterial drugs, ibuprofen and other anti-inflammatory drugs such as analgesic drugs and so on good fast. 1. Infection: the more common clinical bacterial infection, the outer ankle soft tissue swelling pain parts of the surface of the skin more than there is broken, in the A is disinfection on the basis of medicine, can give the relevant antibacterial drugs for treatment, such as common amoxicillin, levofloxacin. 2. Aseptic inflammation: mostly caused by local trauma, strain, cold, etc., because it is aseptic inflammation, so you can use anti-inflammatory and pain-relieving drugs for treatment, the more common are ibuprofen, diclofenac sodium and other non-steroidal anti-inflammatory drugs. 3. Trauma: mostly for the ankle soft tissue contusion, but also does not exclude the possibility of fracture, the clinical need to give ibuprofen and other pain medication, swelling is serious can also be given furosemide and other diuretic drugs to reduce swelling. Soft tissue swelling of the outer ankle simple drug treatment may not be obvious, so you can also be in accordance with the condition, give hot and cold compresses and other physical therapy, and even in the case of necessity to give surgical treatment, the drug needs to be used under the guidance of a professional physician, do not be negligent, so as not to delay the condition.