Rifampicin does not usually cause persistent low-grade fever, but the disease itself may cause persistent low-grade fever. Rifampicin is a commonly used anti-tuberculosis drug, and it is the first-line drug in the anti-tuberculosis drugs, in the anti-tuberculosis treatment, it is widely used, mostly used in the treatment of tuberculosis, intestinal tuberculosis and other tuberculosis diseases, and it will not cause low fever symptoms after using the drug. When using the drug, pay attention to those who are allergic to the drug components, severe liver and kidney insufficiency, pregnant women within 3 months, biliary obstruction is prohibited, after the use of the drug may lead to heartburn, anorexia, fever, drowsiness and other adverse reactions, if the adverse reactions are obvious need to stop the drug and consult a doctor. However, tuberculosis often causes low fever, and can be manifested as low fever in the afternoon, if after the use of rifampicin still appear persistent low fever, may be because the condition has not been effectively controlled, always need to cooperate with the doctor to take medication. In addition, the treatment period should be regularly reviewed to observe the drug treatment, if the drug is not sensitive to the drug, if necessary, you can choose other drugs for treatment, but the use of drugs should be under the guidance of the doctor.