Taking Clozapine for 10 years may lead to drug dependence, serious side effects such as neurological disorders, adverse cardiovascular or respiratory reactions. 1. Drug dependence: Prolonged use may lead to drug dependence, making it difficult to stop taking the drug. 2. Serious side effects: hyperglycemia, diabetes, granulocyte deficiency, etc. 3. Seizure: research speculates that the incidence of epilepsy caused by taking Clozapine for 1 year is about 5%, and its incidence is positively correlated with the dose, the higher the dose the more likely to cause epilepsy. 4. Cardiovascular or respiratory diseases: hypotension, bradycardia, cardiac arrest, myocarditis, dyspnea, pulmonary embolism, etc. 5. Neurological diseases: nerve blocker malignant syndrome, etc.. Clozapine’s main role is to target refractory schizophrenia, belonging to the psychotropic drugs, should be used in strict accordance with the doctor’s instructions, not to be used indiscriminately or long-term use.