Staying up all night with a toothache requires vigilance against diseases such as pericoronitis, acute pulpitis and angina. 1. Pericoronitis: this disease is caused by the third molar eruption difficulties, obstruction, bacterial infection and other factors, there will be pain around the wisdom teeth, biting difficulties and other symptoms, stay up late and lead to low resistance, may induce the disease. 2. Acute pulpitis: the disease is related to bacterial infection, acute physical injury and other factors, acute pulpitis pain often occurs at night, or aggravated, may appear to stay up all night toothache symptoms. 3. angina: the disease is generally caused by ischemia and hypoxia of the heart, patients will have pressure-like pain, pain may radiate to the jaw, which in turn leads to toothache, stay up late when the body’s oxygen demand increases, the heart is overloaded, may induce angina. Toothache may also be caused by other diseases, you can go to the hospital, identify the cause of the relevant treatment, usually to maintain a regular routine.