Tramadol hydrochloride is a class II psychotropic drug, belonging to the opioid analgesics, available in tablets and injections. Widely used clinically is mainly Tramadol Hydrochloride extended-release tablets, mainly used for moderate and severe pain, orthopedic postoperative patients are also applied more. Generally, there are two dosages of 50mg/tablet and 100mg/tablet, and the dosage of the drug can be adjusted according to the patient’s pain level. For patients with hepatic and renal insufficiency, elderly patients, need to reduce the amount of discretion, caution; for children, women and lactating women, it is not recommended to apply. It should be emphasized that Tramadol Hydrochloride is a psychotropic drug, which is prone to drug resistance and drug dependence if used for a long time.