Children with fever and cold hands and feet, according to the specific body temperature, give oral medication or physical cooling to do fever treatment in a timely manner, such as persistent non-relief, should be further examined for the cause of the fever to give targeted treatment. Children’s fever hands and feet cold is a fever phenomenon, is a high fever at the beginning of the small blood vessels at the end of the limbs in a spasmodic contraction state caused by a common pathological manifestations. The first thing to do in the case of children with fever and cold hands and feet is to reduce the fever. If the body temperature does not exceed 38.5 degrees, can be given head placed antipyretic paste and other physical cooling treatment. If the temperature exceeds 38.5 degrees, the fever needs to be reduced by oral acetaminophen and other drugs. After the body temperature returns to normal, the spasm of small blood vessels at the end will be relieved, and the phenomenon of cold hands and feet will be solved. If the fever does not go down or there are convulsions, it is necessary to consult a doctor in time to identify the cause and give targeted treatment. The use of medication should follow the doctor’s instructions.