Slightly increased blood creatinine is commonly caused by physiological factors and pathological factors, generally physiological factors do not need treatment; pathological factors such as primary glomerulonephritis, diabetic nephropathy, etc., need to clarify the cause of the disease and then symptomatic treatment. Usually, the normal range of blood creatinine is 53-106μmol/L for adult men and 44-97μmol/L for adult women, and the reference range varies slightly in different hospitals. Exceeding the normal range of blood creatinine is elevated, which can be caused by physiological and pathological factors. 1. Physiological factors: such as high protein diet, eating a large amount of meat, strenuous exercise, etc. can cause a transient increase in blood creatinine, which can be restored to a healthy level after a vegetarian diet and rest, and does not require treatment. 2. Pathologic factors: (1) primary glomerulonephritis: need to control blood pressure, reduce urinary protein treatment, such as valsartan, Benadryl, etc., when necessary, follow the doctor’s advice need to apply glucocorticoid, immunosuppressant and other treatments, such as methylprednisolone, prednisone acetate, tacrolimus, cyclophosphamide and so on. (2) Diabetic nephropathy: Strict blood sugar control is needed, and commonly used drugs include metformin, acarbose, dagliflozin, insulin and other treatments. The drugs need to be used under the guidance of doctors. When the patient has a high blood creatinine value, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor to improve the examination, to clarify the cause of the disease and then targeted treatment, so as not to delay the condition.