Secondary development of the penis is not possible because during puberty the male penis is subjected to the action of androgens and gradually develops and molds, and the stereotypical shape of the tunica albuginea in particular restricts the possibility of secondary development of the penis. From puberty until the age of 18 or so, the length and diameter of the penis will gradually develop under the action of androgens and will be stereotyped. In particular, the white membrane layer outside the corpus cavernosum of the penis cannot develop again and will not be affected by drugs and other factors to increase in size, so it will limit the unlimited development and enlargement of the penis. If the penis is abnormal, it is recommended that the patient go to the hospital, improve the auxiliary examination, clarify the patient’s condition, and give appropriate treatment by professional physicians.