The difference in the weight of the pulse between the two hands may be a normal physiological phenomenon, or it may be a case of aortitis. Generally speaking, there are some differences in the weight of the pulse between two hands in normal healthy people, which is a normal physiological phenomenon, and there is no need to worry too much. However, if there is a big difference between the two hands, it may be caused by aortitis, and the patient needs to pay attention to it in time. Usually the cause of aortitis is not clear, and is mostly considered to be related to genetics, estrogen levels, autoimmunity, infection and other factors. Its diagnosis is based on one or both sides of the brachial artery, one or both sides of the subclavian artery or the abdominal aorta smell murmur. Patients with aortitis may also have a weakened or absent brachial and femoral arterial vascular pulsation during a generalized vascular physical examination, which may also be manifested as a different pulse intensity in both hands. At the same time, the systolic pressure difference between the two upper limbs of the patient may be greater than 10mmHg, and there will also be angiographic abnormalities, intermittent movement disorders of the limbs and so on. Patients need timely targeted treatment under the guidance of the doctor, timely control and stabilization of the condition. It is recommended that when patients have a different pulse in both hands, they should consult a doctor in time for various examinations and actively cooperate with the doctor to carry out systematic treatment, so as to avoid delaying the condition.