Antibiotics do not affect the production of syphilis-specific antibodies. Syphilis-specific antibodies are the basis for the diagnosis of syphilis. Syphilis-specific antibodies are antibodies produced by the body against protein antigens on the surface of the syphilis spirochete, and antibiotics do not prevent the production of these antibodies, which once produced will remain there for life. Antibiotics have antibacterial or bactericidal effects, the mechanism of action is to inhibit the bacterial cell wall, interfere with bacterial protein synthesis, enhance the permeability of the bacterial cell membrane and inhibit bacterial nucleic acid replication and transcription. It is recommended that patients do not use antibiotics before doing syphilis-related tests, so as not to affect the results of the test, syphilis patients should not blindly use drugs, but under the guidance of the physician treatment.